Gender Differences in Deviance and Health Risk Behaviors Among Young-Adults Undergraduate Students

Background: Deviant and health risk behaviors among young-adults are associated with many adverse outcomes. Objectives: This study aims to evaluate a broad variety of behaviors by gender differences and their contribution to predicting cannabis use in undergraduate students. Method: This research is based on a structured, self-reported anonymous questionnaire distributed to 1,432 young adult undergraduate students at an Israeli University, 533 males and 899 females (mean age 27.4; SD 6.01).

Results: The findings demonstrate a significant proportion of sampled young adults reported to be involved in deviant and health risk behaviors and that all risky behaviors were more frequently significant in males than in females. Among drivers 72% reported speeding, 60% reported failure to keep distance, 44% reported being involved at a car accident as a driver, 40% reported not stopping at a stop sign, and quarter reported driving after drinking alcohol. These findings also expand how certain risk behaviors contribute to predicting cannabis use. Conclusions: The relatively high prevalence of some of these risky behaviors among normative young adults suggests that risky behaviors are considered as normative behavior for this group, especially among man, and therefore, policymakers need to consider prevention and harm reduction interventions relevant to this risk group.     

Sex differences in the genetic architecture of obsessive–compulsive disorder

Obsessive–compulsive disorder (OCD) is a highly heritable complex phenotype that demonstrates sex differences in age of onset and clinical presentation, suggesting a possible sex difference in underlying genetic architecture. We present the first genome‐wide characterization of the sex‐specific genetic architecture of OCD, utilizing the largest set of OCD cases and controls available from the Psychiatric Genomics Consortium. We assessed evidence for several mechanisms that may contribute to sex differences including a sex‐dependent liability threshold, the presence of individual sex‐specific risk variants on the autosomes and the X chromosome, and sex‐specific pleiotropic effects. Furthermore, we tested the hypothesis that genetic heterogeneity between the sexes may obscure associations in a sex‐combined genome‐wide association study. We observed a strong genetic correlation between male and female OCD and no evidence for a sex‐dependent liability threshold model, suggesting that sex‐combined analysis does not suffer from widespread loss of power because of genetic heterogeneity between the sexes. While we did not detect any significant sex‐specific genome‐wide single nucleotide polymorphisms (SNP) associations, we did identify two significant gene‐based associations in females: GRID2 and GRP135, which showed no association in males. We observed that the SNPs with sexually differentiated effects showed an enrichment of regulatory variants influencing expression of genes in brain and immune tissues. These findings suggest that future studies with larger sample sizes hold great promise for the identification of sex‐specific genetic risk factors for OCD.     

Alpha‐band desynchronization reflects memory‐specific processes during visual change detection

Recent work investigating physiological mechanisms of working memory (WM) has revealed that modulation of alpha and beta frequency bands within the EEG plays a key role in WM storage. However, the nature of that role is unclear. In the present study, we examined event‐related desynchronization of alpha and beta (α/β‐ERD) elicited by visual tasks with and without a memory component to measure the impact of a WM demand on this electrophysiological marker. We recorded EEG from 60 healthy participants while they completed three variants on a typical change detection task: one in which participants passively viewed the sample array, passive (WM?); one in which participants viewed and attended the sample array in search of a target color but did not memorize the colors, active (WM?); and one in which participants encoded, attended to, and memorized the sample array, active (WM+). Replicating previous findings, we found that active (WM+) elicited robust α/β‐ERD in frontal and posterior electrode clusters and that α‐ERD was significantly associated with WM capacity. By contrast, α/β‐ERD was significantly smaller in the passive (WM?) and active (WM?) tasks, which did not consistently differ from one another. Furthermore, no such relationship was observed between WM capacity and desynchronization in the passive (WM?) or active (WM?) tasks. Taken together, these results suggest that α‐ERD during memory formation reflects a memory‐specific process such as consolidation or maintenance, rather than serving a generalized role in perceptual gating or engagement of attention.     

The impact of child welfare legislation on domestic violence‐related homicide rates

State‐specific statutes providing legal consequences for perpetrating domestic violence in the presence of a child have been enacted across the United States between 1996 and 2012. This paper examines the impact of this child welfare legislation, using a difference‐in‐differences approach. We find a significant drop in domestic violence‐related homicide rates, when considering a wide range of victim–offender relationships. However, this result does not hold for marital homicides, suggesting that for this subpopulation, the risk of reprisal and consequent reduction in reporting may be counterbalancing the hypothesized deterrent impacts of the legislation.     

Harder,better, faster … Yet stronger? Working conditions and self‐declaration of chronic diseases

The role played by working conditions in worker health status has been widely acknowledged in the literature in general but has received less attention in economics, due to the inherent statistical biases and lack of data available to determine the role of simultaneous and chronic exposures. This study aims to estimate the causal impact of detrimental working conditions on the self‐declaration of chronic diseases in France. Using a rebuilt retrospective lifelong panel and defining indicators for physical and psychosocial strains, I implement a mixed econometric strategy that relies on difference‐in‐differences and matching methods to take into account for selection biases as well as unobserved heterogeneity. For men and women, I find deleterious effects of both types of working conditions on the declaration of chronic diseases after exposure, with varying patterns of impacts according to the nature and magnitude of the strains. These results provide insights into the debate on legal retirement age postponement and justify not only policies being enacted early in individuals' careers in order to prevent subsequent midcareer health repercussions, but also schemes that are more focused on psychosocial risk factors.     

Human papillomavirus vaccination in commercially-insured vaccine-eligible males and females,United States, 2007–2014

BackgroundIn the United States, the Advisory Committee on Immunization Practices (ACIP) has recommended routine human papillomavirus (HPV) vaccination at age 11–12 years since 2006 for girls and since 2011 for boys. ACIP also recommends vaccination through age 26 for females and through age 21 for males; males may be vaccinated through age 26. We describe vaccine uptake in adolescents and young adults using data from MarketScan Commercial Claims and Encounters.MethodsWe analyzed data on persons aged 11–26 years on December 31, 2014 who were continuously enrolled in a MarketScan health plan from age 11 through year 2014, or from 2006 to 2014 if aged ≥11 years in 2006 (916,513 females, 951,082 males). Individuals were grouped based on their age (years) in 2014: 11–12 (born 2002–03), 13–14 (2000–01), 15–16 (1998–99), 17–18 (1996–97), 19–21 (1993–95), and 22–26 (1988–1992). We calculated cumulative coverage with ≥1 HPV vaccine dose by sex, birth cohort, and calendar year.ResultsIn females, the proportion initiating vaccination at age 11–12 years was low in 2008 and 2010 (12.6% and 11.1%) and higher in 2012 (15.7%) and 2014 (19.5%); in males, initiation at age 11–12 was 0.9% in 2010, 8.3% in 2012, and 15.1% in 2014. In females who aged into vaccine eligibility, cumulative coverage by 2014 was higher in older cohorts (17–18: 53%; 15–16: 47%; 13–14: 39%; 11–12: 19.5%). For males, cumulative coverage by 2014 was similar in those aged 13–14, 15–16, and 17–18 years (28.9%, 32.5%, 30.3%), and lower in those aged 11–12 (15.1%), 19–21 (18.4%), and 22–26 years (4.5%).ConclusionThe proportion of males and females initiating vaccination at the recommended ages was low. Although more females than males were vaccinated in all cohorts, the male–female differences were smaller in younger than older cohorts. The trajectory of male vaccination uptake could signal higher acceptability in males.